Trometamol Hydrochloride Tris HCl Tris Hydrochloride CAS 1185-53-1

Customization:	Available
CAS No.:	1185-53-1
Formula:	C4h12clno3

📊 Basic Information

Model NO.

99%

EINECS

214-684-5

Type

Synthesis Material Intermediates

Appearance

Crystal

Quality

Industrial

Colour

White

Specification

≥ 99%

Origin

China

📝 Product Description

Tris(hydroxymethyl)aminomethane Hydrochloride (Tris-HCl)

CAS Number: 1185-53-1
Molecular Formula: C4H12ClNO3
Molecular Weight: 157.596 g/mol
Appearance: White crystalline powder, odorless, moisture-absorbent.
Solubility: Highly soluble in water (~550 g/L at 25°C), slightly soluble in ethanol.

🚀 Application Areas

Biochemical Buffer: Ideal for pH 7.5 - 9.0 ranges; used in nucleic acid extraction, protein electrophoresis (SDS-PAGE), and enzyme reactions.
Medicine and Cosmetics: Functions as an acid-base regulator to stabilize pH in injections, eye drops, and skin-care products.
Molecular Biology: Key component in DNA/RNA extraction reagents (e.g., TE buffer) and reverse-transcription buffers.
Analytical Chemistry: Used as a standard substance for titration and ionic-strength regulation.

⚠️ Safety and Handling

Hazards: Dust is irritating to respiratory tracts, eyes, and skin. High concentrations may cause burns.

Protection: Use masks, gloves, and goggles in well-ventilated areas. Store in sealed containers away from moisture, strong oxidants, and alkaline substances.

Emergency: Rinse skin or eyes with plenty of water for 15 minutes. If ingested, seek medical attention immediately.

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📦 Packaging & Shipping

Liquid Products	Drums of 5kg, 10kg, 25kg, 50kg, 200kg, 250kg; 1000kg IBC drums; TANK containers (20-25 tons).
Solid Products	Bags of 1kg, 2kg, 5kg, 25kg, 500kg, 1000kg; Drums of 25kg and 50kg.

* Packaging can be customized according to specific requirements.

🏢 Professional Capabilities

With over 20 years of experience in the chemical industry, our team provides dynamic import and export services focused on global customer demands. We maintain long-term strategic partnerships with specialized chemical production facilities across China, ensuring high-quality synthesis technology and efficient logistics management. Our facilities utilize advanced equipment and mature technology to provide a stable supply of high-purity chemical products.

❓ Frequently Asked Questions

Q1: What is the primary use of Tris-HCl in laboratories? A1: It is primarily used as a biochemical buffer to maintain a stable pH (7.5-9.0) for nucleic acid extraction, protein electrophoresis (SDS-PAGE), and enzyme reactions.

Q2: How soluble is Tris(hydroxymethyl)aminomethane Hydrochloride in water? A2: It is highly soluble in water, with a solubility of approximately 550 g/L at 25 °C.

Q3: What are the storage requirements for this product? A3: It should be stored in a sealed container, protected from moisture, and kept away from strong oxidants and alkaline substances.

Q4: Can Tris-HCl be used in cosmetics? A4: Yes, it is used as an acid-base regulator in skin-care products and medical drug preparations to stabilize the pH.

Q5: What is the pKa of Tris-HCl? A5: The pKa of Tris-HCl is approximately 8.1 at 25 °C, making it a powerful buffer for biological systems.

Q6: What should I do in case of accidental skin contact? A6: Immediately rinse the affected area with a large amount of clean water. If irritation persists, seek medical advice.